Our Departments
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Email address: levaamoah@noguchi.ug.edu.gh Telephone: +233-302-501178 Fax: +233-302-502182 Department: Immunology
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Biography Dr.Amoah joined the NMIMR in 2009 as a Research Fellow. She obtained her PhD from Georgetown University, USA and focused herPhD thesis work on drug resistant malaria.She specialized in the area of de novogene synthesis, heterologous gene expression and purification of recombinant proteins. To further her malaria research capabilities,Dr.Amoah joined the Malaria Research and Reference Reagent Resource Center(MR4) at the ATCC, USAandstill continues to research in malaria. As a visiting scholar, at the University of Copenhagen she helpedproduce a malaria transmission blocking vaccine candidate. Dr.Amoah’s laboratory is taking an integrated approach to both evaluate malaria transmission in the field and the design of new transmission blocking agents. Her laboratory is screening for anti gametocydal drug activity as well as working on identifying parasite and host genetic traits that influence the infectiousness of circulating Plasmodium gametocytes. Dr.Amoah has also organized and facilitated a number of local and international scientific workshops and conferences and is a member of the University of Ghana Malaria Centre of Excellence. |
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Administrative Role |
Research Fellow
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Research Interests
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1: 14-POI-GHA/A26804 (Dodoo, PI): 2015 – 2019: DANIDA Title: Functional immune-genetic correlates of immunity to malaria – The goalsof this project are to identify correlates of immunity to malaria that incorporate aspects of host genetics, parasite genetics and outputs from functional immunological assays.
2: R01AI069314 - 06A1 (Amoah, PI): 2014-2018: US-NIH Title: Plasmodium falciparum gametocytogenesis – The aim is to better understand the biology and infectiousness of plasmodium falciparum gametocytes
3: URF 6th Call Research Grants (Asamoah, PI) 2013-2015: UG Title: “Identification of novel HLA class I and II-restricted T cell epitopes of Plasmodium falciparum candidate antigens as potential malaria vaccine components”
4: R03 AI103638-01 (Amoah, PI) 2012 – 2015: US-NIH Title: Contributions of Pfs48/45 to malaria transmission blocking immunity - The goal is to validate a malaria transmission blocking vaccine candidate and determine natural levels of transmission blocking antibodies in malaria patients |
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5: UG Malaria Centre for Excellence: 2014 – The goal of this project is to locally produce a vaccine to combat malariaFunding agency: University of Ghana
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GRANT SUPPORT
Funding agency: Aqsens Health Oy 2021 - 2022 Title: Development of a non-invasive malaria diagnostic tool Role: Principal Investigator
Funding agency: NMCP (Ghana) / Global Fund 2021 - 2022 Title: determining whether histidine rich protein gene deletions causing negative hrp2 RDT results among symptomatic patients with confirmed P. falciparum malaria have reached a threshold for change in diagnostic strategy Role: Principal Investigator
Funding agency: MERCK 2020 - 2022 Title: Pan African Vivax and Ovale Network (PAVON) - Investigation of the determinants of Plasmodium vivax and Plasmodium ovale infections in Ghana: parasites prevalence and host factors”. Role: Investigator
Funding agency: Uniformed Services University (USUHS) 2020 - 2022 Title: Strategies to Develop New Field Blood Sample Diagnostics Role: Investigator
Funding agency: Abbott Diagnostics 2020 - 2022 Title: Evaluation of the health and cost effectiveness of the ultra sensitive NxTEK eliminate malaria RDT kit Role: Principal Investigator
Funding agency: Jeunes équipes associées à l’IRD 2020 - 2022 Title: STIMULI: The role of the mosquito bite on the dynamics and infectiousness-to-mosquito of asymptomatic Plasmodium falciparum carriers in Ghana Role: Principal Investigator
Funding agency: Global Fund 2020 - 2021 Title: molecular surveillance of Plasmodium ovale and G6PD deficiency in Ghana Role: Principal Investigator
Funding agency: National Institute for Health 2019 - 2024 Title: Plasmodium falciparum gametocytogenesis in vitro and in vivo (1R01AI147627-01A1) Role: Principal Investigator
Funding agency: EDTCP 2019 - 2023 Title: ‘‘Clinical and immunopathological consequences of chronic HBV and Plasmodium falciparum co-infections”. Role: Co-Investigator
Funding agency: Congressionally Directed Medical Research Program 2019-2022 Title: Novel malaria multi-epitope vaccine design. Role: Investigator
Selected publications
14.Amoah LE, Acquah FK, Nyarko PB, Cudjoe E, Donu D, Ayanful-Torgby R, et al. Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types. Malar J. 2020;19(1):200. 15.Usui M, Prajapati SK, Ayanful-Torgby R, Acquah FK, Cudjoe E, Kakaney C, et al. Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes. Nat Commun. 2019;10(1):2140. 16.Abukari Z, Okonu R, Nyarko SB, Lo AC, Dieng CC, Salifu SP, et al. The Diversity, Multiplicity of Infection and Population Structure of P. falciparum Parasites Circulating in Asymptomatic Carriers Living in High and Low Malaria Transmission Settings of Ghana. Genes (Basel). 2019;10(6). 17.Amoah LE, Abagna HB, Ayanful-Torgby R, Blankson SO, Aryee NA. Diversity and immune responses against Plasmodium falciparum gametocytes in non-febrile school children living in Southern Ghana. Malar J. 2019;18(1):265. 18.Dieng CC, Gonzalez L, Pestana K, Dhikrullahi SB, Amoah LE, Afrane YA, et al. Contrasting Asymptomatic and Drug Resistance Gene Prevalence of Plasmodium falciparum in Ghana: Implications on Seasonal Malaria Chemoprevention. Genes (Basel). 2019;10(7). 19.Amoah LE, Donu D, Abuaku B, Ahorlu CS, Arhinful D, Afari EA, et al. Probing the composition of Plasmodium species contained in malaria infections in the Eastern region of Ghana. BMC Public Health. 2019;19. 20.Acquah FK, Adjah J, Williamson KC, Amoah LE. Transmission-Blocking Vaccines: Old Friends and New Prospects. Infect Immun. 2019;87(6).
Complete list of publications https://pubmed.ncbi.nlm.nih.gov/?term=amoah%2C+linda&sort=date&size=50 Book Chapters
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Name: Dr Linda Eva Amoah, PhD, BSc.