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Name:

Dr. (Mrs.) Evelyn Yayra Afua Bonney

Email address:

Ebonney@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9

Fax:

+233-302-502128/513202

Department:

Virology

Biography

Dr. Mrs. Evelyn Yayra Afua Bonney is a Research Fellow in the Virology Department of the Noguchi Memorial Institute for Medical Research.
She holds a BSc. Honours in Biochemistry and Nutrition, an MPhil in Biochemistry and a PhD in Biochemistry; all from the University of Ghana.

 Her career milestones include laboratory diagnosis and confirmation of the first cases of highly pathogenic avian influenza (H5N1) in 2007 and the receipt of the first ever NMIMR Best Research Assistant Award in 2014.

 She has teaching responsibilities for both undergraduate and postgraduate students in the University of Ghana and these include:

1)  Guest Lecturer, Biochemistry of Viruses and Molecular Epidemiology, Department of Biochemistry, Cell and Molecular Biology

2)  Instructor, MA HIV/AIDS Management, Department of Adult Education and Human Resource Studies, School of Continuing and Distance Education, College of Education

 She is a recipient of HIV Research Trust Scholarship from The HIV Research Trust, UK in 2007 and the Bill and Melinda Gates Foundation-sponsored NMIMR Postdoctoral Fellowship 2015.

 She has co-authored 7 scientific papers in peer-reviewed journals, books and book chapters and a number of conference papers.

Administrative Role

1. Laboratory Supervisor of HIV Genotyping Lab

2. Quality Focal Person for Virology Department

Research Interests

  1. Host factors/proteins influencing viral infections
  2. Antiviral therapy,  susceptibility and resistance

3.      Genetic variability of HIV, HTLV-1, HPV and Influenza viruses;

4.      Co-infections of HIV and other infections among key population

She is interested in identifying appropriate and affordable molecular markers for monitoring patients on antiretroviral therapy, investigating the contribution of host cellular factors to the differential response to HIV infection and viral persistence even during combination antiretroviral therapy, genotyping of high risk human papilloma viruses associated with cervical cancers, genetic variability, antiviral susceptibility and drug resistance implications of HIV-2 and HIV-1/HIV-2 dual infection among patients on HIV-1 based antiretroviral therapy and impact of co-infections such as HPV, HTLV-1, Hepatitis B and Hepatitis C on the development of drug resistance in HIV patients on ART and their clinical outcomes.

Projects:

  1. Contributions of APOBEC3G levels, genetic variation in the vif gene and drug resistance mutations to the outcome of antiretroviral therapy in HIV patients  (Principal Investigator)

 

  1. Human leukocyte antigen (HLA) typing and associated HIV and HTLV-1 genome mutations in Ghana  (Co-Principal Investigator)

 

  1. Biomarkers associated with disease progression in HIV/AIDS patients at an antiretroviral clinic in Ghana (Co-Principal Investigator)

 

  1. Genetic variability of HIV-1 pol gene in antiretroviral drug-naïve Ghanaian patients (Laboratory Supervisor)

 

  1. HIV Drug Resistance Monitoring in HIV/AIDS Patients on ART (Laboratory Supervisor).

 

 

Publications:

 

Articles in Peer-Reviewed Biomedical Journals

1. Brandful JAM, Bonney EY, Asmah RH, Apea-Kubi KA. Onchogenic Human Papillomavirus (HPV) in women in Ghana, Journal of Cancer Research and Experimental Onchology 2014, 6 (4): 31-38

2. Barnor JS, Yamamoto N, Brandful JAM, Ampofo W, Bonney JHK, Bonney E, Odoom JK, Aidoo S, Alale M, Ntim NA, Amoah YO, Ofori SB, Ndzinu J, Aziati ID, Addo NA, Nyarko A, Ido E, Ishikawa K, Yamaoka S. Establishment of In-House Quantitative Real-Time RT-PCR Assay for HIV-1 Viral Load Measurement: Application to Evaluate Efficacy of ART in Ghanaian Patients in an Urban Setting. J AIDS Clin Res 2014, 5: 305

 3. Oliver Barry, Jonathan Powell, Lorna Renner, Evelyn Y Bonney, Meghan Prin, William Ampofo, Jonas Kusah, Bamenla Goka, Kwamena WC Sagoe, Veronika Shabanova and Elijah Paintsil, Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013, 13:476-486

 

4. Evelyn Yayra Bonney, Nii Akwei Addo, Nana Afia Asante Ntim, Frederick Addo-Yobo, Philip Bondzie, Ken-Edwin Aryee, Jacob Barnor, James Brandful, Veronica Bekoe, Sally-Ann Ohene and William Ampofo, Low level of transmitted HIV Drug Resistance at two HIV care centres in Ghana: a threshold survey, Ghana Medical Journal  2013, 47 (2): 82-86

 

5. Bonney EY, Sackey ST and Brandful JAM. Laboratory Diagnosis of Dual HIV-1/HIV-2 Infections in HIV Seropositive Ghanaians East African Medical Journal 2008, 85 (12): 517-523

 6. Delgado, E, Ampofo, WK, Sierra, M, Torpey, K, Perez-A´lvarez, L, Bonney, EY, Mukadi, YD, Lartey, M, Nyarko, C, Amenyah, RN, Thomson, MM. and Rafael Na´ jera. High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana: Molecular Epidemiology from an Antiretroviral Resistance Study, J Acquir Immune Defic Syndr 2008, 48 (5): 599-606

 7. Kinomoto, M, Appiah-Opong R, Brandful, J, Yokoyama, M, Nii-Trebi, N, Ugly-Kwame, E, Sato, H, Ofori-Adjei, D, Kurata, T, Barre-Sinoussi, F, Sata, T. and Tokunaga, K. (2005). HIV-1 Proteases from Drug-Naïve West African Patience Are Differentially Less Susceptible to Protease Inhibitors, Clinical Infectious Diseases 2005, 41: 243-51

 Books

1. Ugly-Kwame, Evelyn Y. (1998). Dietary Patterns, Lifestyle and Physical Development of SSS students in the Ho District of the Volta Region of Ghana, A Dissertation submitted to the University of Ghana in partial fulfillment of the requirements for the award of BSc. Honours degree in Biochemistry and Nutrition.

 2. Ugly-Kwame, Evelyn Y. (2003). Genetic Analysis of HIV strains in Ghanaian HIV-1 and HIV-2 dually seroreactive specimens. A thesis submitted to the University of Ghana, School of graduate Studies in partial fulfillment of the requirements for the award of MPhil degree in Biochemistry.

 3. Bonney Evelyn Yayra A. (2013), Drug Resistance Mutations in HIV Patients on Antiretroviral Therapy in Ghana, A thesis submitted to the University of Ghana, School of graduate Studies in partial fulfillment of the requirements for the award of a Doctor of Philosophy degree in Biochemistry.

 Book Chapter (s)

William K. Ampofo and Evelyn Y. Bonney (2014), Investigations to support the prevention and management of HIV in Ghana, University of Ghana Reader Series Volume 2, Sub-Saharan Publishers, pages 220-229

 She contributed to Chapter 10 (on Viruses) of the book “Molecules of LIFE; Structure and Function at a glance” by Dr. J. P. Adjimani (2008) published by Beno Publications, Accra.

 Conference Presentations

1. Prince K. Parbie, William Ampofo, Julius A. A. Mingle, Jazmin Duque, Meredith McMorrow, Kofi Bonney, Michael Adjabeng, Joseph Amankwa, James Aboagye, Ivy Asante, Evelyn Y. Bonney, Kennedy Brightson, Gabriel Atippoe-Djagmah, Arnold Osei-Wusu, Joseph Asamoah Frimpong, Michael Ntiri, Ekua Houphouet, Badu Sarkodie,  Talla Nzussouo Ndahwouh, Kwadwo Koram, Marc-Alain Widdowson. Human Coronaviruses in Persons with Acute Respiratory Infections in Ghana, 2013-2014 (Poster), 4th African Network for Influenza Surveillance and Epidemiology (ANISE) Meeting, Cape Town International Convention Centre,  4th -6th  December 2014, Cape Town, South Africa

 2. Bonney EY, Sackey ST, Nyarko AK, Addo NA and Ampofo WK, HIV drug resistance mutations in patients on antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons,  Accra, 10-13th September, 2013

 3. Bonney E,  Powell J , Barry O,  Renner L, Prin M, Ampofo W, Kusah J, Goka B, Sagoe KWC, Paintsil E, M184V/K103N is the predominant HIV-1 drug resistance pathway in HIV-infected children failing first-line antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons,  Accra, 10-13th September, 2013

 4. Ivy Asantewaa Asante, Evelyn Yayra Bonney, James Aboagye, Keren Minta- Asare, Christopher Zaab-Yen, Sally- Ann Ohene, Nana Afia Asante Ntim, Prince Parbie, Steven Ayisi Addo, Bernard Dornoo, Veronica Bekoe, Nii Akwei Addo, William Kwabena Ampofo. Serological profiles of HIV infected patients on antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons, Accra, 10-13th September, 2013

 5. Barry O, Powell J, Renner L, Bonney E, Prin M, Ampofo W, Kusah J, Goka B, Sagoe KWC, Northrup VS and Paintsil E. Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana, 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons, Accra, 10-13th September, 2013

 6. E. Y. Bonney, W. Ampofo, E. Delgado, M. Lartey, L. Perez-Alvarez, S-A Ohene, N. A. Addo, National Drug Resistance Expert Committee- William Ampofo; James Brandful; Jacob Barnor; Veronica Bekoe; Kwadwo Asante; Kwamena Sagoe; Margaret Lartey;  Henry Nagai; Sally-Ann Ohene; Yaw Adu- Sarkodie; Bernard Dornoo; Steven Ayisi-Addo; Nii Akwei Addo. Appearance of HIV drug resistance mutations amongst patients on 2nd –line antiretroviral therapy in Ghana (e-poster), 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Abstract No. CDB113, 17-20th July, 2011 Rome, Italy

 7. Bonney EY, Ampofo WK, Delgado E, Lartey M, Perez-Alvarez, L. and Addo N. A. High levels of HIV drug resistance mutations among HIV- positive persons on 2nd-line antiretroviral therapy (ART) in Ghana (Oral), 3rd Ghana Biomedical Convention, 11-13th August 2010.

8. Evelyn Yayra Bonney, Jacob Barnor, Samson Badu Ofori, Norio Yamamoto, William Ampofo, James Brandful, Simeon Aidoo, Ken-Edwin Aryee, Kofi Bonney, Michael Alale, Philip Bondzie, Alexander Nyarko, Koichi Ishikawa, Felix Bampoh, Shoji Yamaoka, Efficacy of Treatment and Drug Resistance Monitoring in HIV-1-infected Patients on Anti- Retrovirals (ARVs) in Koforidua and Tamale in Ghana (Oral), International Symposium on AIDS and Tuberculosis (ISAT), 13-14th Jan, 2010 Sendai, Japan

 9. William Ampofo, Evelyn Bonney, Veronica Bekoe, Kwadwo Asante, Margaret Lartey, Catherine Dawson-Amoah, S.B. Ofori, Joe Tetteh, Sally-Ann Ohene, Ken-Edwin Aryee, Philip Bondzie, James Brandful, Jacob Barnor, Koichi Ishikawa, Ivy Ama Okae and Nii Akwei Addo, The HIV Drug Resistance Threshold Survey (Oral), 30th African Health Sciences Congress, 14-17th October 2009, Accra.

 10. E. Delgado, W. Ampofo, K. Torpey, E. Ugly-Kwame, M. Sierra, M. Munoz, Y. Mukadi, C. Nyarko, E. Vazquez de Parga, Y. Vega, R. Asare, R. Amenyah, R. Carmona, G. Casado, M. Thomson, R. Najera, High Prevalence of HIV-1 unique recombinant forms (URFs) in Ghana involving CRF02_AG, CRF06_cpx and CRF09_cpx, (Poster), 3rd IAS Conference on HIV Pathogenesis and Treatment, 24th-27th July 2005, Rio de Janeiro

 11. E. Delgado, W. Ampofo, K. Torpey, E. Ugly-Kwame, M. Sierra, M. Munoz, Y. Mukadi, C. Nyarko, E. Vazquez de Parga, Y. Vega, R. Asare, R. Amenyah, R. Carmona, G. Casado, M. Thomson, R. Najera. Characterization of near full-length genomes of subtype A3 and A3/CRF02_AG recombinant forms in Ghana (Poster), XVI International AIDS Conference, 13th-18th August 2006, Toronto Canada

 12. Bonney  EY, Sackey ST and Brandful JAM., Genetic Analysis of HIV strains in Ghanaian HIV-1 and HIV-2 dually seroreactive specimens (Oral), Fourth Annual Research Meeting, Noguchi Memorial Institute for Medical Research, 2004, Accra

 13. E Y Ugly-Kwame, W O Kumi, J A M Brandful, K Ishikawa, Prevalence of HIV-Related Opportunistic Diseases among Ghanaian HIV/AIDS Patients (Poster), XIV International AIDS Conference, 7th -12th July 2002, Barcelona

 

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Noguchi

P.O. Box LG 581
Legon, Accra

+233 030 2501178/79

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