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Name:

Prof. Regina Appiah-Opong, PhD, MPhil, BSc.

Email address:

Rappiah-opong@noguchi.ug.edu.gh

Telephone:

+233(0)302501178/9 Ext 227

Fax:

+233(0)302502182

Department:

Clinical Pathology

Biography

Prof. Appiah Opong has devoted much of her working life to biomedical research, mostly at NMIMR. She is a Toxicologist at the Clinical Pathology Department and is a Research fellow and Head of the Department. Her PhD studies were focused on pharmacokinetic drug interactions, expressing drug metabolizing enzymes and determining the effects of drug candidates on them.

In 2001, she undertook further training in molecular biology techniques at the National Institute for Infectious Diseases (NIID) Tokyo, Japan and during this time contributed significantly to the construction of a DNA cassette vector that was useful for drug susceptibility testing of anti-HIV drugs.

Regina Appiah Opong is also a part-time lecturer at the Department of Biochemistry, Cell and Molecular Biology, University of Ghana and the Principal Investigator on the University’s Research grant funded project that is conducting onshore assessment of the Jubilee oil field in the Western region of Ghana. She has been involved in projects in the area of drug development, evaluating the efficacy and safety of drugs and medicinal plants and environmental contaminants, particularly heavy metals and aflatoxins.

Prof. Appiah Opong is a collaborator on the JICA/JST/Nagasaki International University/Centre for Scientific Research into Plant Medicine/NMIMR research project that is studying anti-HIV and anti-typanosomiasis compounds in Ghanaian medicinal plants. She is also collaborating with the Pharmacology Department of Yale University Medical School on chemical and biological fingerprinting of some Ghanaian medicinal plants. She is a member of a multidisciplinary team that is investigating the efficacy of Ghanaian medicinal plants used by Traditional Medicine Practitioners to manage cancer.

Administrative Role

Head of Department

Research Interests

Toxicology/Pharmacology

·         Drug development – Anticancer, antimalaria

·         Drug-drug/drug-herb/drug-food interactions

·         Environmental contaminants – Heavy metals, aflatoxins

Projects:

·         Title: Assessment of the seasonality of rotavirus infection in Ghana

Role: Research assistant

·         Title: Determination of glyoxalase – I activity levels in peripheral blood of Ghanaian Africans with or without Plasmodium falciparum/ Role: Research assistant

·         Title: Investigation of lead levels and related findings occurring in Ghanaian subjects occupationally exposed to lead

Role: Research assistant

·         Title: Studies on lead exposure in urban and rural school children in Ghana

Role: Research assistant

·         Title: Biliary excretion in persons with low blood glutathione levels Role: Research assistant

·         Title: Toxicity of low levels of methylglyoxal on blood glutathione and effects on glucose tolerance in mice

Role: Research assistant

·         Title: Human breast milk storage and the glutathione content

Role: Research assistant

·         Title: Association between low blood glutathione levels and haptoglobulin phenotypes in pregnant women

Role: Research assistant

·         Title: Effects of Ghanaian vegetables on aflatoxin biotransformation Role: PI

·         Title: Cytochrome P450-mediated drug-drug and herb-drug interaction studies on drugs and herbal preparations used to treat malaria, tuberculosis and HIV/AIDS

Role: PI

·         Title: Studies on anti-viral and anti-parasitic compounds from selected Ghanaian medicinal plants

Role: Co-investigator

·         Title: Screening of Ghanaian medicinal plants for anticancer bioactive agents

Role: Co-investigator

·         Title: Crude Oil Drilling: Onshore environmental assessment of the Jubilee oil field in the Western Region of Ghana

Role: PI

·         Title: Evaluation of the susceptible of HIV-1 proteases from drug-naïve West African patients to protease inhibitors

Role: Co-investigator

·         Chemical and biological fingerprinting of Ghanaian medicinal plants Role: Co-PI

Publications:

·         R. Appiah-Opong, N-A. Ankrah, A.K. Nyarko. (2014) In vitro and in vivo assessment of Ghanaian antimalarial medicinal plants. In K.A. Koram, C.S.K. Ahorlu, M.D. Wilson, D. Yeboah-Manu and K.M. Bosompem (Eds.), Towards effective disease control in Ghana: Research and policy implication (Vol. 1 Malaria pp. 95-105). University of Ghana Reader: Sub-Saharan Publishers.

·         R. Appiah-Opong, N-A. Ankrah, A.K. Nyarko, M. Ofosuhene. (2014) Phytomedicines: Safety and efficacy studies on Ghanaian medicinal plants. In KA Koram, CSK Ahorlu, MD Wilson, D Yeboah-Manu and KM Bosompem (Eds.), Towards effective disease control in Ghana: Research and policy implication (Vol. 2 Other infectious diseases and health systems pp. 275-289). University of Ghana Reader: Sub-Saharan Publishers.

·         R. Appiah-Opong, A.K. Nyarko, D. Dodoo, F.N. Gyang, K.A. Koram, and N.K. Ayisi.  (2011) Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in vitro Plasmodium falciparum culture system. Ghana Medical Journal, 45:143-150.

·         N.K. Ayisi, R. Appiah-Opong, B. Gyan, K. Bugyei and F. Ekuban (2011). Plasmodium falciparium: Assessment of selectivity of action of chloroquine, Alchornea cordifolia, Ficus polita and other Drugs by a Tetrazolium-Based Colorometric Assay. Malaria Research Treatment. 2011, Article ID 816250, doi:10.4061/2011/816250.

  • R. Appiah-Opong, J.N.M. Commandeur, E. Istyastono, J. J. Bogaards and N.P.E. Vermeulen (2009). Inhibition of glutathione S-transferases activity by curcumin analogues. Xenobiotica, 39: 302-311.
  • R. Appiah-Opong, J.N.M. Commandeur, C. Axson and N.P.E. Vermeulen (2008). Interactions between cytochromes P450 and glutathione S-transferases and Ghanaian medicinal plants. Food Chemical Toxicology, 46: 3598-3603.
  • R. Appiah-Opong, I. de Esch, J.N.M. Commandeur, M. Andarini, N.P.E. Vermeulen (2008). Inhibition of recombinant human cytochrome P450 mediated metabolism by curcumin analogues and related structure-activity relationships. European Journal Medicinal Chemistry, 43: 1621-1631.
  • R. Appiah-Opong, Commandeur, J.N.M., Vermeulen, N.P.E., (2007). Curcumin: Pharmacokinetics, metabolism, and potential for drug-drug/food interactions. Proceedings of International symposium on recent progress in curcumin research, Gadjah Mada University, Indonesia, pp 57-73.
  • R. Appiah-Opong, J.N.M. Commandeur, B. van Vugt-Lussenburg, N.P.E. Vermeulen (2007). Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology, 235: 83-91.
  • M. Kinomoto,* R. Appiah-Opong,* J.A.M. Brandful, M. Yokoyama, N. Nii-Trebi, E. Ugly-Kwame, H. Sato, D. Ofori-Adjei, T. Kurata, F. Barre-Sinoussi, T. Sata, K. Tokunaga (2005). HIV-1 proteases from drug-naïve West African patients are differentially less susceptible to protease inhibitors. Clinical Infectious Diseases, 41: 243-251. *contributed equally
  • N-A. Ankrah, I. K. E. Quaye, R. Appiah-Opong, C. Dzokoto, F. A. Ekuban and K. Teye (2003). Association between low blood glutathione levels and haptoglobulin phenotypes in pregnant women. Ghana Medical Journal, 37: 35-38.
  • N-A. Ankrah, R. Appiah-Opong and C. Dzokoto (2000). Human breast milk storage and the glutathione content. Journal of Tropical Pediatrics, 46: 111-113.
  • N-A. Ankrah and R. Appiah-Opong, (1999). Toxicity of low levels of methylglyoxal: depletion of blood glutathione and adverse effect on glucose tolerance in mice. Toxicological Letters, 109: 61-67.
  • N-A. Ankrah, S. K. Dunyo, A. K. Nyarko, R. Appiah-Opong and M. Ofosuhene (1998). Biliary excretion in persons with low blood glutathione levels. East African Medical Journal, 75: 204-207.
  • N-A. Ankrah, A. K. Nyarko, M. Ofosuhene, R. Appiah-Opong and Y. A. Akyeampon (1998). Lead exposure in urban and rural school children in Ghana. African Journal of Health Sciences, 5: 85-88.
  • N-A. Ankrah, Y. Kamiya, R. Appiah-Opong, Y. A. Akyeampon and M. M. Addae (1996). Lead levels and related findings occurring in Ghanaian subjects occupationally exposed to lead. East African Medical Journal, 73: 375-379.
  • N-A. Ankrah, A.Sittie, R. Appiah-Opong and I. Ackom (1996). Glyoxalase – I activity levels in peripheral blood of Ghanaian Africans with or without Plasmodium falciparum. African Journal of Health Sciences, 3: 41-43.
  • G. E. Armah, J. A. A. Mingle, A. K. Dodoo, A. Anyanful, R. Antwi, J. Commey and F. K. Nkrumah (1994). Seasonality of rotavirus infection in Ghana. Annals of Tropical Paediatrics, 14: 223-230.

·         S. Tetteh, D.K. Dodoo, R. Appiah-Opong and I. Tuffour (2014). Cytotoxicity, antioxidant and glutathione S-transferase inhibitory activity of palladium II chloride complexes bearing nucleobase ligands. Transition Metals Chemistry, Article ID doi: 10.1007/s11243-014-9848-3.

·         S. Tetteh, D.K. Dodoo, R. Appiah-Opong and I. Tuffour (2014). Spectroscopic characterization, in vitro cytotoxicity and antioxidant activity of mixed ligand Palladium (II) Chloride complexes bearing nucleobases. Journal of Inorganic Chemistry, Article ID 586131, doi: 10.1155/2014/586131.

  • K. Kyeremah, O. Asamoah, S.K. Botchie, I. Tuffour, T. Uto, R. Appiah-Opong (2013). Bioactivity data for Eunicellin-based diterpenes isolated from Acalycigorigia sp. International Journal of Applied Chemistry, 9:141-150.
  • K. Kyeremeh, F.W. Agbemafo, R. Appiah-Opong (2013). Quantitative analysis of chemical contaminants in Ghanaian Herbal alcoholic bitters. International Journal of Chemistry and Applications, 5(2):153-167.

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P.O. Box LG 581
Legon, Accra

+233 030 2501178/79

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