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Title

Dr.

Name

Benjamin Abuaku

Academic Qualifications

BSc, MPH, Dip., PhD

Professional Qualification

 

Email address

babuaku@noguchi.ug.edu.gh

Telephone (office)

+233-302-501178/9

Fax number

+233 302 502182

School

Noguchi Memorial Institute for Medical Research (NMIMR)

Department

Epidemiology

Short Bios /CV

Dr. Abuaku, an Epidemiologist and Research Fellow in the Noguchi Memorial Institute for Medical Research, obtained his Bachelor and Master degrees in the University of Ghana in 1991 and 2000, respectively. His Master degree thesis focused on patterns of antimalarial drug use in Ghana. In 2002 he obtained a post-graduate diploma in Research Methodology in the University of Copenhagen. He obtained his PhD degree in 2010 in the Central South University, China. His PhD thesis focused on Tuberculosis treatment outcomes in Hunan province of China andthe Eastern region of Ghana. Dr. Abuaku coordinated antimalarial therapeutic efficacy studies in six sentinel sites between 1998 and 2004, the results of which contributed to the change of the national malaria treatment policy in 2005. He continues to provide efficacy data on Artemisinin-based combination Therapies (ACTs) to the National Malaria Control Programme and the World Health Organization. He is a member of the American Society of Tropical Medicine and Hygiene; a Fellow of the Danish International Development Agency; a member of the National Malaria Case Management Technical Working Group (Ministry of Health, Ghana); a member of the University of Ghana Malaria Centre of Excellence; and a visiting Scientist to the School of Public Health, Central South University, China.

 

Administrative Role

Staff performance appraisal

Research Interest

1. Infectious disease epidemiology

2. Clinical trials

3. Rational drug use

4. Quality Assurance in health care facilities

5. Impact of flood hazards

Research Projects completed within the past 5 years

1.      Characterization of molecular markers of Plasmodium falciparum antimalarial drug resistance from ten regions of Ghana (2009 to 2013)

Funding agency:US Naval Medical Research Unit (NAMRU)/ Global Emerging Infections Surveillance and Response System (GEIS)

Role: Co- Investigator

2.      Prevalence of Plasmodium falciparumparasitaemia in Obuasi (2006 to 2014)

Funding agency: AngloGold Ashanti (AGA)

Role: Co-Principal Investigator

3.      Phase 1, Double-Blinded, Placebo-Controlled Dosage-Escalation Study of the Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults. (2011 to 2012)

Funding agency: National Institute of Health (NIH)

Role: Co-Investigator

4.      Surveillance for antimalarial drug resistance in Ghana. (2011 to 2012)

Funding agency: US Naval Medical Research Unit (NAMRU) / Global Emerging Infections Surveillance and Response System (GEIS)

Role: Co-Investigator

5.      Rapid Mortality Monitoring in Ghana (2011 to 2014)

Funding agency: Canadian International Development Agency (CIDA) / Health Metrics Network (HMN), WHO

Role: Co-Investigator

6.      Prevalence of Plasmodium falciparumparasitaemia and anaemia in children under five years of age at baseline and following annual vs. biannual indoor residual spraying (IRS) in Bunkpurugu-Yunyoo district, northern Ghana. (2010 to 2014)

Funding agency: The U.S President’s Malaria Initiative (PMI)

Role: Co-Principal Investigator

On-going research projects

  1. Tracking malaria prevalence in 30 sentinel sites in Ghana. (2013 to date)

Funding agency: U.K Department for International Development (DFID)

Role: Principal Investigator

2.      Monitoring of the efficacy of antimalarial drugs for the treatment of uncomplicated malaria in Ghana.(2005 to date)

Funding agency: The Global Fund to Fight AIDS, Tuberculosis and Malaria

Role: Co-Principal Investigator

3.      Impact of Distinct Eco-epidemiology on Malaria Drug Resistance in Ghana (2013 to date)

Funding agency: National Institute of Health (NIH)

Role: Co-Investigator

4.      Gametocyte development- Plasmodium falciparum. (2015 to date)

Funding agency: National Institute of Health (NIH)

Role: Co-Investigator

 

List of publications

Articles

1.      Mary Bushman, Lindsay Morton, Nancy Duah, Neils Quashie, Benjamin Abuaku, Kwadwo A. Koram, Pedro Rafael Dimbu, Mateusz Plucinski, Julie Gutman, Peter Lyaruu, S. Patrick Kachur, Jacobs C. De Roode and VenkatachalamUdhayakumar. Within-host competition and drug resistance in the human malaria parasite Plasmodium faclciparum. Proc. R. Soc. B 2016; 283:20153038.

2.      Benjamin Abuaku, Nancy Duah, Lydia Quaye, Neils Quashie, KeziahMalm, Constance Bart-Plange and KwadwoKoram. Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of uncomplicated malaria in two ecological zones in Ghana. Malaria Journal 2016; 15:6

3.      Chen M, Deng J, Li W, Su C, Xia Y, Wang M, Li X, Abuaku B.K, Tan H and Wen S.W. The relationship between chitotriosidase activity and tuberculosis. Epidemiol Infect 2015; 143:3196-3202.

4.      Mengshi Chen, Jing Deng, Wufei Li, Dan Lin, Congxu Su, Mian Wang, Xun Li, Benjamin KwakuAbuaku, Hongzhuan Tan and Shi Wu Wen. Impact of tea drinking upon tuberculosis: a neglected issue. BMC Public Health 2015; 15:515.

5.      Mengshi Chen, Ying Liang, Wufei LI, Mian Wang, Li Hu, Benjamin KwakuAbuaku, Xin Huang, Hongzhuan Tan and Shi Wu Wen. Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis. BMC Infectious Diseases 2015; 15:151.

6.      Mengshi Chen, Jing Deng, Congxu Su, Jun Li, Mian Wang, Benjamin KwakuAbuaku, ShiMin Hu, Hongzhuan Tan, Shi Wu Wen. Impact of passive smoking, cooking with solid fuel exposure, and MBL/MASP-2 gene polymorphism upon susceptibility to tuberculosis. International Journal of Infectious Diseases 2014; e1-e6.

7.      Mengshi Chen, Abuaku Benjamin Kwaku, Youfang Chen, Xin Huang, Hongzhuan Tan, Shi Wu Wen. Gender and regional disparities of tuberculosis in Hunan, China. International Journal for Equity in Health 2014; 13:32.

8.      Neils B Quashie, Nancy O Duah, Benjamin Abuaku, Lydia Quaye, Ruth Ayanful-Torgby, George A Akwoviah, Margaret Kweku, Jacob D Johnson, Naomi W Lucchi, VenkatachalamUdhayakumar, Christopher Duplessis, Karl C Kronmann, Kwadwo A Koram. A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs. Malaria Journal 2013; 12:450.

9.      Duah O Nancy, Matrevi A Sena, de Souza K Dziedzom, Binnah D Daniel, Tamakloe M Mary, Opoku S Vera, Onwona O Christiana, Narh A Charles, Quashie B Neils, Abuaku Benjamin, Duplessis Christopher, Kronmann C Karl, Koram A Kwadwo. Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy. Malaria Journal 2013; 12:377. 

10.  Benjamin Abuaku, Nancy Duah, Lydia Quaye, Neils Quashie and KwadwoKoram. Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana. Malaria Journal 2012; 11:388.

11.  Nancy O. Duah, Ben Abuaku, Neils Quashie, Karl Kronman, KwadwoKoram. Surveillance of molecular markers of Sulphadoxine-Pyrimethamine resistance in Ghana after the change of malaria treatment policy.American Journal of Tropical Medicine and Hygiene 2011; 85 (6): 201.

12.  MinningPeng, Aizhong Liu, Jia Zhou, Shiwu Wen, Shuoqi Li, Tubao Yang, Xingli Li, Xin Huang, Benjamin Abuaku, Hongzhuan Tan. Association between Posttraumatic Stress Disorder and Pre-flood Behavioral characteristics among Children Aged 7-15 years in Hunan, China. Medical Principles and Practice 2011; 20 (4):336-40.

13.  Li Xinhua, Liao Bingrong, Liu Jian, Tan Hongzhuan, Huang Wenfan, Abuaku Benjamin, Liu Wei, Huang Xin, Wen Shiwu. Prevalence and risk factors for childhood obesity in Changsha and Shenzhen in China. J Cent South Univ (Med Sci) 2010; 35 (1): 11-16.

14.  Benjamin K. Abuaku, Hongzhuan Tan, Xingli Li, Mengshi Chen, Xin Huang. A comparative analysis of tuberculosis treatment success between Hunan province of China and Eastern Ghana. Medical Principles and Practice 2010; 19 (6):451-6.

15.  Benjamin Abuaku, Hongzhuan Tan, Xingli Li, Mengshi Chen, Xin Huang. Treatment default and death among Tuberculosis patients in Hunan, China. Scandinavian Journal of Infectious Diseases 2010: 42: 281 – 287.

16.  B. K. Abuaku, J. Zhou, Xinhua Li, S. Li, A. Liu, T. Yang, H. Tan. Morbidity and mortality among populations suffering floods in Hunan, China: The role of socioeconomic status. Journal of flood risk management 2009; 2:222-228.

17.  K.A. Koram, L. Quaye and B. Abuaku. Efficacy of Amodiaquine/Artesunate combination therapy for uncomplicated malaria in children under five years in Ghana. Ghana Medical Journal 2008; 42 (2):55-60.

18.  Xin Huang, Hongzhuan Tan, Jia Zhou, Tubao Yang, Abuaku Benjamin, Shi Wu Wen, Shouqi Li, Aizhong Liu, Xinhua Li, Shuidong Fen, Xinli Li. Flood hazards in Hunan province of China: an economic loss analysis. Natural Hazards 2008; 47 (1):65 – 73.

19.  ShuidongFeng, Hongzhuan Tan, Abuaku Benjamin, Shiwu Wen, Aizhong Liu, Jia Zhou, Shuoqi Li, Tubao Yang, Yanbo Zhang, Xinhua Li, Gangqian Li. Social Support and Posttraumatic Stress Disorder among Flood Victims in Hunan China. Annals of Epidemiology 2007; 17 (10):827 – 833.

20.  Quashie NB, Duah NO, Abuaku B., Koram KA. The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs. Annals of Tropical Medicine and Parasitology 2007; 101 (5):391-8.

21.  Duah NO, Wilson MD, Ghansah A, Abuaku B, Edoh D, Quashie NB, Koram KA. Mutations in Plasmodium falciparumchloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria. Journal of Tropical Pediatrics 2007; 53 (1):27-31.

22.  Abuaku BK, Koram KA, Binka F (2005). Antimalarial prescribing practices: a challenge to malaria control in Ghana. Med PrincPract2005; 14:332-337.

23.  Kwadwo KA, Abuaku B, Duah N, Quashie N. Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. ActaTropica. 2005; 95:194-203.

24.  Benjamin K. Abuaku, Kwadwo A. Koram and Fred N. Binka (2004). Antimalarial drug use among caregivers in Ghana. African Health Sciences Journal.4 (3): 171-177.

Book Chapters

25.  N.B Quashie, N.O Duah, L. Quaye, B. Abuaku, K.A. Koram. Antimalarial drug resistance surveillance in Ghana: the complementary role of in-vitro antimalarial drug sensitivity testing, pp. 135-150. In: Towards safe and effective treatment of diseases in Ghana: contributions from clinical pharmacology. University of Ghana Readers Clinical Sciences series No. 13. (Eds.) George Obeng Adjei and David Ofori-Adjei. Digibooks Ghana Ltd Tema, Ghana, 2015.

26.  Abuaku Benjamin, Quaye Lydia, Quashie Nancy, Quashie Neils, Koram Kwadwo. Managing antimalarial drug resistance in Ghana: the importance of surveillance, pp. 7-18. In: Towards Effective Disease Control in Ghana: Research and Policy Implications. Volume1, Malaria. University of Ghana Reader Series. (Eds.) Kwadwo Ansah Koram, Collins Stephen K. Ahorlu, Michael David Wilson, Dorothy Yeboah-Manu and Kwabena Mante Bosompem. Sub-Saharan Publishers Accra, Ghana, 2014.

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