|Research Interests :
I have undertaken several studies on the epidemiology and control of malaria in an attempt to understand the factors underlying the distribution and occurrence of malaria in the country. The studies have spanned straight forward descriptive studies to map out the distribution to intervention studies identifying novel agents for the control of the disease. A large proportion of studies have focused on the epidemiology of drug resistance infections and the studies initiated in 1998 provided the efficacy data for the change in policy of drug treatment by the National Malaria Control Programme in 2005, when we showed that the efficacy of chloroquine in the treatment of uncomplicated malaria had fallen to below 50% in some places in the country.
Since then, the sites used for these studies have been adopted by the NMCP as sentinel sites for the monitoring of parasite responses to treatment. The surveillance is being coordinated by my group at the Institute. We have also expanded these studies to identify novel mutations that are associated with reduced treatment responses.
I have recently led investigations into the utility of intermittent preventive treatment in children in reducing fevers at the community level and found that this is able to reduce prevalence of malaria by almost 80% after 1 year and the low prevalence has persisted up to 2 years after cessation of the treatment programme (Ahorlu et.al., 2010; Ahorlu et.al., 2011).