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kbosompem

Name:Prof. Kwabena Mante Bosompem
 Telephone:+233-302-501178/9, +233-302-501180
 Fax: +233 -302-502182

 Department: Parasitology

 Administrative Role: Director

 


Prof. Kwabena Mante Bosompem is the Director of the Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana.
He led a team of researchers at NMIMR to develop a cost effective, non-invasive, rapid field-applicable monoclonal antibody-based dipstick assay for urinary schistosomiasis.

Prof. K. M Bosompem served as member of the World Health Organization (WHO) Task Force on African Trypanosomiasis, and he was consultant to the WHO on several occasions.  He also served as a member of the Editorial Board of “Parasitology International”. He has lectured in Applied Parasitology, Microbiology/Immunology and Veterinary Microbiology and trained students including undergraduates; Higher National Diplomas (HND), BSc, M.Phils and Ph.Ds. from several universities including the University of Ghana, the University of Cape Coast, Ghana, Kwame Nkrumah University of Science and Technology, Ghana, and the Erasmus University, Rotterdam, Netherlands. He has over “70 publications in International Journals and he has contributed to pioneering work on toxoplasmosis and biomining.


Prof. Bosompem has been Chairman of the Research Board of the College of Health Sciences (comprised of the University of Ghana School of Medicine and Dentistry, Noguchi Memorial Institute for Medical Research, School of Public Health, School of Nursing, School of Pharmacy, School of Biomedical and Allied Health Sciences). He was a member of the Board of the National Biosafety Authority of Ghana. He is also a Member of Ghana’s Committee for implementation of United Nations Security Council Resolution (UNHCR) 1540 on Chemical Biological Radiological and Nuclear (CBRN) materials. He is also Team Leader of the Sub-committee on – Biological non-proliferation; and member of CBRN Centres of Excellence “Project 17” for “Establishing a national response plan in Ghana and Kenya for responding to unauthorized events involving CBRN”. He was also National President of the Ghana Red Cross Society.

His biography was published in the Millennium Edition of Marquis WHO’s WHO (2000) recognising today’s global leaders in every important field of endeavour. Through his interest in social research and development, he initiated the philosophy and concept of comprehensive community mobilization through Community Directed Development, and he is the Founder of Community Directed Development Foundation (CDDF).

Research Interests

  • Advancing one health, integrating accurate diagnostics, limiting zoonoses, disease prevention and elimination.
  • Developing health systems, strategic partnerships and safety nets for livelihoods improvement.
  • Strengthening local governance and people’s participation for reaching development targets in health, including SDGs.

 

 Projects

 

Recent Publications 

  1. Kulinkina AV, Kosinski KC, Plummer JD, Durant JL, Bosompem KM, Adjei MN, Griffiths JK, Gute DM, Naumova EN. (2017). Indicators of improved water access in the context of schistosomiasis transmission in rural Eastern Region, Ghana. Sci Total Environ. 2017 Feb 1;579:1745-1755. doi: 10.1016/j.scitotenv.2016.11.140. PMID:
  2. Tekwu EM, Bosompem KM, Anyan WK, Appiah-Opong R, Owusu KB, Tettey MD, Kissi FA, Appiah AA, Penlap Beng V, Nyarko AK. (2017). In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study. J Parasitol Res. 2017;2017:2583969. doi: 10.1155/2017/2583969. Epub 2017 Feb 28. PMID: 28348881 [PubMed].
  3. Lodh N, Mikita K, Bosompem KM, Anyan WK, Quartey JK, Otchere J, Shiff CJ, (2017). Point of care diagnosis of multiple schistosome parasites: Species-specific DNA detection in urine by loop-mediated isothermal amplification (LAMP). Acta Trop. 2017 Sep;173:125-129. doi: 10.1016/j.actatropica. 2017.06.015. Epub 2017 Jun 12. PMID: 28619672 [PubMed].
  4. Markakpo US, Bosompem KM, Dzodzomenyo M, Danso-Appiah A, Essuman EE, Anyan WK, Suzuki M, Stephens JK, Anim-Baidoo I, Asmah RH, Ofori MF, Madjitey P, Danquah JB, Frempong NA, Kwofie KD, Amoa-Bosompem M, Sullivan D Jr, Fobil JN, Quakyi IA (2016). Minimising invasiveness in diagnostics: developing a rapid urine-based monoclonal antibody dipstick test for malaria. Trop Med Int Health. 2016 Oct;21(10):1263-1271. doi: 10.1111/tmi.12744. PMID:
  5. Alnasser Y, Ferradas C, Clark T, Calderon M, Gurbillon A, Gamboa D, McKakpo US, Quakyi IA, Bosompem KM, Sullivan DJ, Vinetz JM, Gilman RH. (2016). Colorimetric Detection of Plasmodium vivax in Urine Using MSP10 Oligonucleotides and Gold Nanoparticles. PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005029. doi: 10.1371/journal.pntd.0005029. Erratum in: PLoS Negl Trop Dis. 2016 Nov 9;10 (11):e0005143. PMID:
  6. Alnasser Y, Ferradas C, Clark T, Calderon M, Gurbillon A, Gamboa D, McKakpo US, Quakyi IA, Bosompem KM, Sullivan DJ, Vinetz JM, Gilman RH (2016). Correction: Colorimetric Detection of Plasmodium vivax in Urine Using MSP10 Oligonucleotides and Gold Nanoparticles. PLoS Negl Trop Dis. 2016 Nov 9;10(11):e0005143. doi: 10.1371/journal.pntd.0005143. PMID:
  7. Danso-Appiah A, Minton J, Boamah D, Otchere J, Asmah RH, Rodgers M, Bosompem KM, Eusebi P, De Vlas SJ (2016). Accuracy of point-of-care testing for circulatory cathodic antigen in the detection of schistosome infection: systematic review and meta-analysis. Bull World Health Organ. 2016 Jul 1;94(7):522-533A. doi: 10.2471/BLT.15.158741. Review. PMID:
  8. Kosinski KC, Kulinkina AV, Tybor D, Osabutey D, Bosompem KM, Naumova EN. (2016). Agreement among Four Prevalence Metrics for Urogenital Schistosomiasis in the Eastern Region of Ghana (2016). Biomed Res Int. 2016;2016:7627358. doi: 10.1155/2016/7627358. PMID:
  9. Tekwu EM, Anyan WK, Boamah D, Baffour-Awuah KO, Keyetat Tekwu S, Penlap Beng V, Nyarko AK, Bosompem KM. (2016). Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends. Biomark Res. 2016 Nov 22;4:21. Review. PMID:
  10. Yirenya-Tawiah DR, Ackumey MM, Bosompem KM. (2016). Knowledge and awareness of genital involvement and reproductive health consequences of urogenital schistosomiasis in endemic communities in Ghana: a cross-sectional study. Reprod Health. 2016 Sep 21;13(1):117. PMID:

 

 

 

 

 

The management and staff of the Noguchi Memorial Institute for Medical Research (NMIMR) wish to congratulate Dr. Samuel Dadzie, a medical entomologist at the Institute on his new appointment as a Senior Research Fellow.
Dr. Samuel Kweku Dadzie holds a PhD in Vector Biology from the Liverpool School of Tropical Medicine, UK.

 He has extensive experience in medical entomology in both field and laboratory techniques. His research interest focuses on vector biology with emphasis on the application of modern methods to address the burden of vector-borne diseases.He coordinates the field and laboratory components of entomology projects in the Department of Parasitology of the Institute. He also provides training on basic entomological techniques in Ghana and in many countries outside Ghana .

 Dr. Dadzie is a member of several committees in Ghana including the Malaria Vector Control Oversight Committee and Malaria Research Advisory Group of the Ghana National Malaria Control Programme, Intra-country Advisory Committee on Neglected Tropical Diseases, and Technical Advisory Committee of Zoomlion Nationwide Mosquito Control Programme among others. He is the Focal person for African Network of Vector Resistance (ANVR/WHO/AFRO) in Ghana.  He recently developed the National Insecticide Resistance Monitoring Partnership for the Ghana National Malaria Control Program and currently the Program Director. Dr Dadzie also teaches and supervises students at the African Postgraduate Programme of Insect Sciences (ARPPIS), University of Ghana. He is also a member of American Society of Tropical Medicine and Hygiene.

Dr. Dadzie has about 30 publications to his name.

The Institute wishes you well as you climb to attain new goals in life.




Title

Dr.

Name:

Bright Adu

Academic Qualification

PhD, MPhil, BSc.

Professional Qualification

Immunogeneticist

Email address:

badu@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9

Fax number:

+233-302-502128/513202

School/Institute

Noguchi Memorial Institute for Medical Research

Department:

Immunology

Short BIOS/CV

Personal Statement

My passion is to make immense contribution to improving the quality of human health by expanding our current knowledge in the field of human immunology and immunogenetics of infectious and non-communicable diseases through research and teaching.

 

Education

Jun. 2014: PhD. Bio medicine, University of Copenhagen, Copenhagen, Denmark

Thesis: Immunogenetics of human malaria: Relevance of Fc gamma receptor and RNASE3 gene polymorphisms to the outcome of Plasmodium falciparum infection

 

Feb. 2011: MPhil. Biochemistry, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana

Thesis:Immunological and genetic correlates of immunity to Plasmodium falciparum malaria

 

Jun. 2006: BSc. Biochemistry (First Class Division), Kwame Nkrumah University of Science & Technology, Kumasi, Ghana

 

Professional Experience

2015-Present         Research Fellow, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

2014-2014            Post-Doctoral Fellowship (GLURP Team), Statens

Serum Institute, Copenhagen, Denmark

2010-2011       Research Assistant, Statens Serum Institute,

Copenhagen, Denmark

2007-2010             Senior Research Assistant Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

2006-2007             Teaching Assistant, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

 Workshops and Conferences Attended

Merck Africa Luminary Meeting 2015, Nairobi, Kenya, November 2015

 2015 International Year of Light & Light-based Technologies, Accra, Ghana, September 2015

2nd Nordic Malaria Conference, Copenhagen,Denmark, September, 2012

o   Oral presentation: Fc Gamma Receptor IIIB (FcγRIIIB) Polymorphisms Are Associated with Clinical Malaria in Ghanaian Children

 

16th Human Genome Meeting 2012, Sydney,Australia, March 2012

o   Oral presentation: Fc Gamma Receptor IIIB (FcγRIIIB) Polymorphisms Are Associated with Clinical Malaria in Ghanaian Children

 1st Research Program in Global Health Annual Research Meeting, Copenhagen, Denmark, November, 2011.

o   Oral presentation: Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children

 

International T-Cell Assay Workshop for Assessment of T-Cell Immunity to Malaria.Venue: Noguchi Memorial Institute For Medical Research, Accra, Ghana. January 2010

 

Training in Molecular Techniques for Genetics Studies. Venue: Statens Serum Institut, Copenhagen, Denmark. March to May 2009

 

Training in Tissue Culture using Epstein-Barr virus to transform and immortalize B-cells. Venue: Immunology Department of Noguchi Memorial Institute for Medical Research, Accra, Ghana. January 2008

 

1st AFRO-IMMUNOASSAY (AIA) workshop on standardization of immunoassays for assessment of malaria vaccine candidate antigens, Venue: Noguchi Memorial Institute for Medical Research, Accra, Ghana, 27th to 31stJanuary 2008

 2nd AIA WORKSHOP on standardization of immunoassays for assessment of malaria vaccine candidate antigens, Venue: Noguchi Memorial Institute for Medical Research, Accra, Ghana, 18th to 21st  November 2008

 Good Clinical Practice (GCP) Training for DMID Clinical Studies. Venue: Noguchi Memorial Institute for Medical Research, Accra, Ghana. April 2008

 Awards

Best PhD Presentation: 1st Research Program in Global Health Annual Research Meeting, Copenhagen, Denmark, November, 2011.

 

Research interest

My research interest is mainly focused on understanding immunogenetic factors that influence the outcome of host pathogen interactions and the mechanisms of pathogenesis mediated by these factors. Currently, my research includes identification of immunological and genetic correlates of protective immunity against malaria towards the discovery of an efficacious malaria vaccine that can prevent disease and/or interrupt transmission. I am keenly interested in human structural genomic/genetic variations and how these impact on susceptibility to both infectious and non-communicable diseases. I am also involved in malaria and helminthes co-infections studies and how helminths infestation impact on the immune response during Plasmodium falciparum infection.

Research Projects completed (within the past 5 years):

None

On-going research projects

Title: Functional immune-genetic correlates of malaria immunity

Duration: 2015 to 2019

Role: Co-PI

 

Title: Malaria – helminth co-infection in Southern Ghana: issue and challenges in vaccine development against placental malaria

Duration: 2016-2018

Role: Investigator

List of Publications:

  1. Adu B,Cherif MK, Bosomprah S, Diarra A, Arthur FK, Dickson EK, Corradin G, Cavanagh DR, Theisen M, Sirima SB, Nebie I, Dodoo D: Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas. Malar J 2016, 15:123.
  2. Tiendrebeogo RW, Adu B, Singh SK, Dziegiel MH, Nebie I, Sirima SB, Christiansen M, Dodoo D, Theisen M: Antibody dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children. Open Forum Infect Dis 2015; doi: 10.1093/ofid/ofv044
  3. Tiendrebeogo RW, Adu B, Singh SK, Dodoo D, Dziegiel MH, Mordmuller B, Nebie I, Sirima SB, Christiansen M, Theisen M: High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparumparasitaemia in bioassays. Malar J 2014, 13:412.
  4. Theisen M, Roeffen W, Singh SK, Andersen G, Amoah L, van de Vegte-Bolmer M, Arens T, Tiendrebeogo RW, Jones S, Bousema T, Adu B,Dziegiel MH, Christiansen M, Sauerwein R: A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages. Vaccine 2014, 32:2623-2630.
  5. Adu B,Jepsen MP, Gerds TA, Kyei-Baafour E, Christiansen M, Dodoo D, Theisen M: Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. J Infect Dis 2014.
  6. Adu B, Dodoo D, Adukpo S, Hedley PL, Arthur FK, Gerds TA, Larsen SO, Christiansen M, Theisen M: Fc Gamma Receptor IIIB (FcgammaRIIIB) Polymorphisms Are Associated with Clinical Malaria in Ghanaian Children. PLoS One 2012, 7(9):e46197.
  7. Adu B, Dodoo D, Adukpo S, Gyan BA, Hedley PL, Goka B, Adjei GO, Larsen SO, Christiansen M, Theisen M: Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. PLoS One 2011, 6(12):e29465.

 


Professor  William Ampofo, PhD

Department: Virology

Email: wampofo@noguchi.mimcom.org

Phone: +233 302-501178/9

 Short Bios/CV

Dr. William Ampofo is a Senior Research Fellow, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana. He has a Bachelor’s degree from University of Ghana Legon, and a PhD. from the Tokyo Medical and Dental University, Tokyo, Japan.

Research Interests:

His research interests include molecular and serological investigations of viruses, prevention of viral infections, anti-viral therapy and viral disease.

 Career milestones include the laboratory discovery of the first Ghanaian case of HIV in 1986, first isolation of wild type poliovirus in Ghana, confirmation of first cases in 2007 of highly pathogenic avian influenza H5N1 virus in Ghanaian poultry and establishment of the National Influenza Centre in Ghana 2007. Recently, he supervised the laboratory detection (December 2011) of the first ever cases of Lassa fever virus infection in humans and rodents in Ghana.

 Dr Ampofo also has teaching responsibilities in the University of Ghana, overseeing both undergraduate and postgraduate research. His publications cover medicine, immunology, microbiology, biological sciences and molecular biology. He has a keen interest in the area of maternal and child health and has collaborated in studies on HIV, Hepatitis B and Influenza. He is a recipient of a Commonwealth Scholarship Commission Fellowship as a Visiting Scientist at World Health Organization Collaborating Centre for Influenza, National Institute for Medical Research, U.K.

 In recognition of his significant contribution towards the establishment of surveillance for influenza in Ghana, Dr Ampofo was awarded a United States (US) Department of Defence – Global Emerging Infections Surveillance and Response program Medal of Achievement.  He is a key member of Institutional (ie Biosafety) and national committees (such as HIV Drug Resistance, Laboratory Quality and Pandemic Influenza). Dr. Ampofo has participated in several pandemic influenza preparedness and response activities in Ghana. He has served internationally on temporary assignments with the World Health Organization (WHO), Commonwealth Secretariat Health Division, US Department of Defense, German International Development Agency and the US Agency for International Development. 

In 2010, he was appointed a member of the WHO Strategic Advisory Group of Experts Working Group for Influenza vaccines and Immunization. Since October 2011, he is one of three African region representatives serving on the WHO Pandemic Influenza Preparedness Advisory Group. August 2012 also saw his appointment by the WHO Director-General to a new two year membership of the Global Action Plan Advisory Group for Influenza Vaccines. Dr Ampofo is also currently the American Society for Microbiology Ambassador for Ghana.

He is married with three children and this former national cricketer is currently President of the Ghana Cricket Association.

Details of Research Projects  -

 Title:Quality Assurance of HIV testing in Ghana

Role: Co – Investigator

Budget: about $10,000.0

Period: 1998 to 2003

 Title:       Rural outreach on HIV/AIDS and STD awareness:Birim-North District of Ghana.

Role:Project Coordinator

Budget: GH¢120,000.0 (US $80,000.0)

Period:2000 to 2002

 

Title:Prevention of Mother to Child Transmission (PMTCT) of HIV in Ghana.

Role:Project Coordinator

Budget: GH¢675,000.0 (US $450,000.0)

Period:2000 to 2005

 

Title:Ghana Demographic and Health Survey - HIV testing.

Role:Coordinator - HIV testing

Budget: NMIMR GH¢22,500.0 (US $ 15,000.0)

Period:2003

 

Title: Characteristics of Hepatitis B virus in Ghana.

Role:Co-Investigator

Period:2004

Budget: unavailable

 

Title: Assessment of Serological responses to Hepatitis B and Haemophilus Influenza B

Vaccines in infants receiving vitamin A supplementation.

Role:Co-Investigator

Budget: NMIMR GH¢9,600.0 (US $ 6,400.0)

Period:2004 to 2006

 

Title: Randomized Controlled Trial of SAVVY and HIV in Ghana

Role:Co-Principal Investigator

Budget: NMIMR GH¢2,550,000.0 (US$ 1,700,000.0)

Period:2004 to 2006

 

Title: HIV/AIDS laboratory research support

Role:Principal Investigator

Budget: NMIMR GH¢9,197.0     (US $6,131.0)

Period:2004 to 2006

 

Pathogenesis, National Institute of Health Carlos III, Madrid. Funding was provided by USAID and the United Kingdom Department for International Development.

 

Title:HIV Workplace Policy and Prevention Programme: University ofGhana

Role:Resource Person

Period:2005 to 2007

 

Title:Laboratory Study on Archived Samples: Estimating HIV Incidence Rates Among

Pregnant Women in Ghana

Role:Co-Investigator

Budget: NMIMR GH¢9,000.0   (US $6,131.0)

Period:2005 to 2006

 

Title:    HIV and Sexually Transmitted Infections (STIs) - Neisseria gonorrhoea and

Chlamydia trachomatis - Study among Female Sex Workers in Accra and Kumasi

Role:    Co-Investigator

Budget:           NMIMR GH¢60,000.0 (US $39,700.00)

Period: 2005 to 2006 

 

Title:    Development of Reference Guide on Status Disclosure and Partner Notification for

HIV Voluntary Counselling and Testing (Trainers /Counsellors).

Role:    Resource Person / Academic Supervisor

Budget:NMIMR GH¢ 16,500.0     (US $11,000)

Period: 2005 to 2008 

 

Title:    Research to Improve Infant Nutrition and Growth (RIING)

Role:    Co-Investigator

Period:2005 to 2009

 

Title:    HIV Interactive, Training, Education and Development Centre.

Role:    Resource Person

Period:2006 to 2009

 

Title:    Assessment of susceptibility of Hepatitis B virus genotypes to RNA interference-

mediated gene silencing.

Role:    Co-Principal Investigator

Budget: NMIMR    GH¢97,500.0 ($65,000.00)

Period: 2006 to 2008 

 

Title:    Study on the effect of malaria on HIV disease progression in Kumasi, Ghana

Role:    Resource Person

Budget:           NMIMR GH¢58,500.0    ($39,000.00)

Period: since2008

 

Title:    Surveillance for Influenza virus in acute respiratory illness in Ghana.

Role:    Co-Principal Investigator

Budget: NMIMR GH¢1,050,000.0     (US $700,000.00)

Period: since2007 

 

Title:    Isolation and Characterization of Influenza virus in Children in Accra

Role:    Academic supervisor

Budget:           GH¢ 5,000.0(US $3,333.3)

Period: 2007 - 2009 

 

Title:    A study to assess HIV-1 compartmentalization in Th1 versus Th2 lymphocytes in

individuals co-infected with parasitic infections and HIV-1 in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢37,500.0     (US $25,000.0)

Period: 2007 - 2009 

 

Title:    Characterization of Prevailing HIV Recombinant Strains in Ghanaian Patients on Anti-

Retroviral Therapy in Koforidua, Ghana.

Role:    Co-Investigator

Budget:           Unavailable

Period: since 2007

 

Title:    Monitoring of Emergence of HIV Drug Resistance at Antiretroviral Sites in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢300,000.0     (US $200,000.0)

Period: since 2008 

 

Title:    HIV Drug Resistance Threshold Survey.

Role:    Co-Principal Investigator

Budget:           GH¢255,000.0    (US $170,000.0)

Period: since 2008 

 

Title:    Influenza Viruses in Wild Birds in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢37,500.0     (US $$25,000.0)

Period: 2008 - 2009 

 

Title:    Ecology of avian influenza viruses in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢54,000.0     (US $$36,000.0)

Period: 2010 - 2011 

 

Title:    Socio-cultural and Bio-Behavioural survey in High/Low HIV prevalent areas in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢300,000.0     (US $200,000.0)

Period: 2010 - 2011 

 

Title:    The Ghana Men’s Study: Integrated Biological Behavioural Surveillance Surveys with Population Size Estimation among Men who have Sex with Men.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢ 299,635.5     (US $199,757.0)

Period: 2010 - 2012

 

Title:    Mapping, Size Estimation, Behavioral and Biological Survey of Female Sex Workers

(FSWs) and Behavioural Survey of their Clients in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢316,971.3     (US $211,314.0)

Period: 2010 - 2011

 

Title:    A population based project to determine the epidemiology and burden of pandemic and

seasonal influenza and risk factors for severe illness in a rural population in Ghana

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢146,055.0     (US $97,370.0)

Period: 2011 - 2012

 

Title:    Epidemiology, Prevention and Treatment of Influenza and Other Respiratory Infections in Ghana in

Role:    Principal Investigator

Budget:           NMIMR GH¢9.0M     (US $4.5M)

Period: 2012 to 2017

 

Publications

1.      Maina EK, Bonney EY, Bukusi EA, Sedegah M, Lartey M, Ampofo WK. CD4+ T cell counts in initiation of antiretroviral therapy in HIV infected asymptomatic individuals; controversies and inconsistencies. Immunology Letters. 2015 Oct 22. pii: S0165-2478(15)30046-8.

2.      Prince Godfred Agbenohevi, John Kofi Odoom, Samuel Bel-Nono, Edward Owusu Nyarko, Mahama Alhassan,David Rodgers, Fenteng Danso, Richard D Suu-Ire, Joseph Humphrey Kofi Bonney, James Aboagye,Karl C Kronmann, Chris Duplessis, Buhari Anthony Oyofo and William Kwabena Ampofo. Biosecurity measures to reduce influenza infections in military barracks in Ghana. BMC Research Notes (2015) 8:14. DOI 10.1186.

3.      Joseph Tuffour, Evelyn Owusu-Mireku, Marie-Therese Ruf, Samuel Aboagye, Grace Kpeli, Victor Akuoku, Janet Pereko, Albert Paintsil, Kofi Bonney, William Ampofo, Gerd Pluschke, and Dorothy Yeboah-Manu. Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study. American Journal of Tropical Medicine and Hygiene, 93(2), 2015, pp. 216–223.

4.      William K. Ampofo, Eduardo Azziz-Baumgartner, Uzma Bashir, Nancy J. Cox, Rodrigo Fasce, Maria Giovanni, Gary Grohmann, Sue Huang, Jackie Katz, Alla Mironenko, Talat Mokhtari-Azad, Pretty Multihartina Sasono, Mahmudur Rahman, Pathom Sawanpanyalert, Marilda Siqueira, Anthony L. Waddell, Lillian Waiboci, John Wood, Wenqing Zhang, Thedi Ziegler, WHO Writing Group1. Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014.

 

5.      Nelson MI, Njouom R, Viboud C, Niang MND, Kadjo H, Ampofo W, Adebayo A, Tarnagda Z, Miller MA, Holmes EC, Diop OM.  Multi-year persistence of two pandemic A/H1N1 influenza virus lineages in West Africa J Infect Dis. 2014; 210 (1): 121-125.

 

6.      Nii-Trebi Nl, Brandful JAM, Ampofo WK, Musah BO, Barnor JS Tokunaga K. Rapid detection of HIV-1 subtypes in Ghana by heteroduplex mobility assay. Int J Biomedical Science and Engineering. 2014; 2: (4), 33-37.

 

7.      Cassels S, Jenness SM, Biney AAE, Ampofo WK, Dodoo FN. Migration, sexual networks, and HIV in Agbogbloshie, Ghana Demographic Research 2014; 31: 861-888.

8.      Jenness SM, Biney AA, Ampofo WK, Nii-Amoo Dodoo F, Cassels S.Minimal coital dilution in Accra, Ghana. Journal of Acquired Immune Deficiency Syndromes. 2015; 69(1):85-91.

9.      Barry O, Powell J, Renner L, Bonney E, Prin M, Ampofo W, Kusah J, Goka B, Sagoe K, Veronika Shabanova V, Elijah Paintsil E.  Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013; 13:476  doi:10.1186/1471-2334-13-476

10.  Boru WG, Kikuvi G, Omollo J, Abade A, Amwayi S, Ampofo W, Luman ET, Oundo J. Aetiology and factors associated with bacterial diarrhoeal diseases amongst urban refugee children in Eastleigh, Kenya: A case control study. African Journal of Laboratory Medicine 2013;2 (1) 6 pages. doi: 10.4102/ajlm.v2i1.63

11.  Kronmann KC, Ampofo W, Nzussouo T, Wasfy MO, Agbenohevi P, Carroll J, Diabate M, Sourabie S, Puplampu N, Clemens M, Oyofo BA.  Building military influenza surveillance capacity in West Africa Mil Med. 2013; 178(3):306-14. doi: 10.7205/MILMED-D-12-00273.

12.  Schoub BD, Gessner BD, Ampofo W, Cohen AL, Steffen CA. Afriflu2 Second international workshop on influenza vaccination in the African continent. 8 November 2012, Cape Town (South Africa). Vaccine. 2013, 31(35):3461-6.

  1.  “Yaoundé-like virus in resident wild bird, Ghana.” Williams, Richard A. J., Vázquez, Ana, Asante, Ivy, Bonney, Kofi, Odoom, Shirley,Puplampu, Naiki, Ampofo, William, Sánchez-Seco, María Paz, Tenorio, Antonio and Peterson, A. Townsend. African Journal of Microbiology Research Vol. 6(9), pp. 1966-1969, 9 March, 2012.
  2. Maternal HIV is associated with reduced growth in the first year of life among infants in the Eastern region of Ghana: the Research to Improve Infant Nutrition and Growth (RIING) Project" by Lartey, Anna; Marquis, Grace; Mazur, Robert; Pérez-Escamilla, Rafael; Brakohiapa, Lucy; Ampofo, William; Sellen, Daniel; Adu-Afarwuah, Seth.  Maternal and Child Nutrition. 2012. DOI: 10.1111/j.1740-8709.2012.00441.x

15.  Dzotsi EK, Ohene SA, Asiedu-Bekoe F, Amankwa J, Sarkodie B, Adjabeng M, Ofei A, Oduro J, Atitogbe D, Bonney JHK, Nimo Paintsil SC, Ampofo W.  The first cases of Lassa fever infection in Ghana. Ghana Medical Journal. 2012; 46(3): 166 – 170.

  1. Preterm delivery and low birth weight among neonates born to HIV-positive and HIV-negative Ghanaian women. Laar A. K., Ampofo W., Tuakli J. M., Norgbe G. K. and Quakyi I. A. Journal of Public Health and Epidemiology Vol. 2(9), pp. 224–237, December 2010
  2. Maternal HIV is associated with reduced growth in the first year of life among infants in the Eastern region of Ghana.  Anna Lartey, Grace S Marquis, Rafael Perez-Escamilla, Robert Mazur, Lucy Brakohiapa, William Ampofo and Dan Sellen. FASEB J March 17, 2011 25:216.2
  3. What predicts non-retention in microbicide trials? Feldblum PJ, Halpern V, Lie CC, Obunge O, Ogunsola F, Ampofo W, Opoku K.  ContempClin Trials. 2011 Jul; 32(4):512-6. Epub 2011 Mar 5. 
  4. Improving influenza vaccine virus selection. Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, Edwards S, Ferguson N, Grohmann G, Hay A, Katz J, Kullabutr K, Lambert L, Levandowski R, Mishra AC, Monto A, Siqueira M, Tashiro M, Waddell AL, Wairagkar N, Wood J, Zambon M, Zhang W.  Influenza Other Respi Viruses. (2011 Aug 8). doi: 10.1111/j.1750-2659.2011.00277.x. Epub

 

Accepted manuscripts

20.  The first cases of Lassa fever in Ghana. EK Dzotsi, SA Ohene, F Asiedu-Bekoe, J Amankwa, B Sarkodie, M Adjabeng, AM Thouphique, RNA Ofei, J Oduro, D Atitogbe, JHK Bonney, SC NimoPaintsil and W Ampofo. Ghana Medical Journal  GMJ-2012-02-0031.

21.  Virological Surveillance of Influenza-Like Illness among Children in Ghana, 2008-2010. Joseph H.K. Bonney, Karl C. Kronmann, Christina P. Lindan, Ivy A. Asante, Prince Parbie, James Aboagye, Joseph Amankwah, John Kofi Odoom, Michael Adjabeng, NdahwouhTallaNzussouo, Lawson Ahadzie, Robert Vince Barthel, Clair Cornelius, George Amofah, BuhariOyofo, William K. Ampofo.  2012. The Journal of Infectious Diseases MS #49145R1.

 

 

Name:

Dr. (Mrs.) Evelyn Yayra Bonney

Email address:

ebonney@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9

Fax:

+233-302-502128/513202

Department:

Virology

Biography

Dr. Mrs. Evelyn Yayra Afua Bonney is a Research Fellow in the Virology Department of the Noguchi Memorial Institute for Medical Research.
She holds a BSc. Honours in Biochemistry and Nutrition, an MPhil in Biochemistry and a PhD in Biochemistry; all from the University of Ghana.

 Her career milestones include laboratory diagnosis and confirmation of the first cases of highly pathogenic avian influenza (H5N1) in 2007 and the receipt of the first ever NMIMR Best Research Assistant Award in 2014.

 She has teaching responsibilities for both undergraduate and postgraduate students in the University of Ghana and these include:

1)  Guest Lecturer, Biochemistry of Viruses and Molecular Epidemiology, Department of Biochemistry, Cell and Molecular Biology

2) Instructor, MA HIV/AIDS Management, Department of Adult Education and Human Resource Studies, School of Continuing and Distance Education, College of Education

 She is a recipient of HIV Research Trust Scholarship from The HIV Research Trust, UK in 2007 and the Bill and Melinda Gates Foundation-sponsored NMIMR Postdoctoral Fellowship 2015.

 She has co-authored 7 scientific papers in peer-reviewed journals, books and book chapters and a number of conference papers.

 

Administrative Role

1. Laboratory Supervisor of HIV Genotyping Lab

2. Quality Focal Person for Virology Department

 

Research Interests

  1. Host factors/proteins influencing viral infections
  2. Antiviral therapy,  susceptibility and resistance

3.      Genetic variability of HIV, HTLV-1, HPV and Influenza viruses;

4.      Co-infections of HIV and other infections among key population

She is interested in identifying appropriate and affordable molecular markers for monitoring patients on antiretroviral therapy, investigating the contribution of host cellular factors to the differential response to HIV infection and viral persistence even during combination antiretroviral therapy, genotyping of high risk human papilloma viruses associated with cervical cancers, genetic variability, antiviral susceptibility and drug resistance implications of HIV-2 and HIV-1/HIV-2 dual infection among patients on HIV-1 based antiretroviral therapy and impact of co-infections such as HPV, HTLV-1, Hepatitis B and Hepatitis C on the development of drug resistance in HIV patients on ART and their clinical outcomes.

Projects:

  1. Contributions of APOBEC3G levels, genetic variation in the vif gene and drug resistance mutations to the outcome of antiretroviral therapy in HIV patients  (Principal Investigator)

  1. Human leukocyte antigen (HLA) typing and associated HIV and HTLV-1 genome mutations in Ghana  (Co-Principal Investigator)

  1. Biomarkers associated with disease progression in HIV/AIDS patients at an antiretroviral clinic in Ghana (Co-Principal Investigator)

  1. Genetic variability of HIV-1 pol gene in antiretroviral drug-naïve Ghanaian patients (Laboratory Supervisor)

  1. HIV Drug Resistance Monitoring in HIV/AIDS Patients on ART (Laboratory Supervisor).

Publications:

Articles in Peer-Reviewed Biomedical Journals

1. Brandful JAM, Bonney EY, Asmah RH, Apea-Kubi KA. Onchogenic Human Papillomavirus (HPV) in women in Ghana, Journal of Cancer Research and Experimental Onchology 2014, 6 (4): 31-38

2. Barnor JS, Yamamoto N, Brandful JAM, Ampofo W, Bonney JHK, Bonney E, Odoom JK, Aidoo S, Alale M, Ntim NA, Amoah YO, Ofori SB, Ndzinu J, Aziati ID, Addo NA, Nyarko A, Ido E, Ishikawa K, Yamaoka S. Establishment of In-House Quantitative Real-Time RT-PCR Assay for HIV-1 Viral Load Measurement: Application to Evaluate Efficacy of ART in Ghanaian Patients in an Urban Setting. J AIDS Clin Res 2014, 5: 305

 3. Oliver Barry, Jonathan Powell, Lorna Renner, Evelyn Y Bonney, Meghan Prin, William Ampofo, Jonas Kusah, Bamenla Goka, Kwamena WC Sagoe, Veronika Shabanova and Elijah Paintsil, Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013, 13:476-486

4. Evelyn Yayra Bonney, Nii Akwei Addo, Nana Afia Asante Ntim, Frederick Addo-Yobo, Philip Bondzie, Ken-Edwin Aryee, Jacob Barnor, James Brandful, Veronica Bekoe, Sally-Ann Ohene and William Ampofo, Low level of transmitted HIV Drug Resistance at two HIV care centres in Ghana: a threshold survey, Ghana Medical Journal  2013, 47 (2): 82-86

5. Bonney EY, Sackey ST and Brandful JAM. Laboratory Diagnosis of Dual HIV-1/HIV-2 Infections in HIV Seropositive Ghanaians East African Medical Journal 2008, 85 (12): 517-523

 6. Delgado, E, Ampofo, WK, Sierra, M, Torpey, K, Perez-A´lvarez, L, Bonney, EY, Mukadi, YD, Lartey, M, Nyarko, C, Amenyah, RN, Thomson, MM. and Rafael Na´ jera. High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana: Molecular Epidemiology from an Antiretroviral Resistance Study, J Acquir Immune Defic Syndr 2008, 48 (5): 599-606

 7. Kinomoto, M, Appiah-Opong R, Brandful, J, Yokoyama, M, Nii-Trebi, N, Ugly-Kwame, E, Sato, H, Ofori-Adjei, D, Kurata, T, Barre-Sinoussi, F, Sata, T. and Tokunaga, K. (2005). HIV-1 Proteases from Drug-Naïve West African Patience Are Differentially Less Susceptible to Protease Inhibitors, Clinical Infectious Diseases 2005, 41: 243-51

Books

1. Ugly-Kwame, Evelyn Y. (1998). Dietary Patterns, Lifestyle and Physical Development of SSS students in the Ho District of the Volta Region of Ghana, A Dissertation submitted to the University of Ghana in partial fulfillment of the requirements for the award of BSc. Honours degree in Biochemistry and Nutrition.

 2. Ugly-Kwame, Evelyn Y. (2003). Genetic Analysis of HIV strains in Ghanaian HIV-1 and HIV-2 dually seroreactive specimens. A thesis submitted to the University of Ghana, School of graduate Studies in partial fulfillment of the requirements for the award of MPhil degree in Biochemistry.

 3. Bonney Evelyn Yayra A. (2013), Drug Resistance Mutations in HIV Patients on Antiretroviral Therapy in Ghana, A thesis submitted to the University of Ghana, School of graduate Studies in partial fulfillment of the requirements for the award of a Doctor of Philosophy degree in Biochemistry.

Book Chapter (s)

William K. Ampofo and Evelyn Y. Bonney (2014), Investigations to support the prevention and management of HIV in Ghana, University of Ghana Reader Series Volume 2, Sub-Saharan Publishers, pages 220-229

 She contributed to Chapter 10 (on Viruses) of the book “Molecules of LIFE; Structure and Function at a glance” by Dr. J. P. Adjimani (2008) published by Beno Publications, Accra.

Conference Presentations

1. Prince K. Parbie, William Ampofo, Julius A. A. Mingle, Jazmin Duque, Meredith McMorrow, Kofi Bonney, Michael Adjabeng, Joseph Amankwa, James Aboagye, Ivy Asante, Evelyn Y. Bonney, Kennedy Brightson, Gabriel Atippoe-Djagmah, Arnold Osei-Wusu, Joseph Asamoah Frimpong, Michael Ntiri, Ekua Houphouet, Badu Sarkodie,  Talla Nzussouo Ndahwouh, Kwadwo Koram, Marc-Alain Widdowson. Human Coronaviruses in Persons with Acute Respiratory Infections in Ghana, 2013-2014 (Poster), 4th African Network for Influenza Surveillance and Epidemiology (ANISE) Meeting, Cape Town International Convention Centre,  4th -6th  December 2014, Cape Town, South Africa

2. Bonney EY, Sackey ST, Nyarko AK, Addo NA and Ampofo WK, HIV drug resistance mutations in patients on antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons,  Accra, 10-13th September, 2013

3. Bonney E,  Powell J , Barry O,  Renner L, Prin M, Ampofo W, Kusah J, Goka B, Sagoe KWC, Paintsil E, M184V/K103N is the predominant HIV-1 drug resistance pathway in HIV-infected children failing first-line antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons,  Accra, 10-13th September, 2013

 4. Ivy Asantewaa Asante, Evelyn Yayra Bonney, James Aboagye, Keren Minta- Asare, Christopher Zaab-Yen, Sally- Ann Ohene, Nana Afia Asante Ntim, Prince Parbie, Steven Ayisi Addo, Bernard Dornoo, Veronica Bekoe, Nii Akwei Addo, William Kwabena Ampofo. Serological profiles of HIV infected patients on antiretroviral therapy in Ghana (Oral), 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons, Accra, 10-13th September, 2013

5. Barry O, Powell J, Renner L, Bonney E, Prin M, Ampofo W, Kusah J, Goka B, Sagoe KWC, Northrup VS and Paintsil E. Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana, 3rd National HIV and AIDS Research Conference, College of Physicians and Surgeons, Accra, 10-13th September, 2013

6. E. Y. Bonney, W. Ampofo, E. Delgado, M. Lartey, L. Perez-Alvarez, S-A Ohene, N. A. Addo, National Drug Resistance Expert Committee- William Ampofo; James Brandful; Jacob Barnor; Veronica Bekoe; Kwadwo Asante; Kwamena Sagoe; Margaret Lartey;  Henry Nagai; Sally-Ann Ohene; Yaw Adu- Sarkodie; Bernard Dornoo; Steven Ayisi-Addo; Nii Akwei Addo. Appearance of HIV drug resistance mutations amongst patients on 2nd –line antiretroviral therapy in Ghana (e-poster), 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Abstract No. CDB113, 17-20th July, 2011 Rome, Italy

7. Bonney EY, Ampofo WK, Delgado E, Lartey M, Perez-Alvarez, L. and Addo N. A. High levels of HIV drug resistance mutations among HIV- positive persons on 2nd-line antiretroviral therapy (ART) in Ghana (Oral), 3rd Ghana Biomedical Convention, 11-13th August 2010.

8. Evelyn Yayra Bonney, Jacob Barnor, Samson Badu Ofori, Norio Yamamoto, William Ampofo, James Brandful, Simeon Aidoo, Ken-Edwin Aryee, Kofi Bonney, Michael Alale, Philip Bondzie, Alexander Nyarko, Koichi Ishikawa, Felix Bampoh, Shoji Yamaoka, Efficacy of Treatment and Drug Resistance Monitoring in HIV-1-infected Patients on Anti- Retrovirals (ARVs) in Koforidua and Tamale in Ghana (Oral), International Symposium on AIDS and Tuberculosis (ISAT), 13-14th Jan, 2010 Sendai, Japan

 9. William Ampofo, Evelyn Bonney, Veronica Bekoe, Kwadwo Asante, Margaret Lartey, Catherine Dawson-Amoah, S.B. Ofori, Joe Tetteh, Sally-Ann Ohene, Ken-Edwin Aryee, Philip Bondzie, James Brandful, Jacob Barnor, Koichi Ishikawa, Ivy Ama Okae and Nii Akwei Addo, The HIV Drug Resistance Threshold Survey (Oral), 30th African Health Sciences Congress, 14-17th October 2009, Accra.

10. E. Delgado, W. Ampofo, K. Torpey, E. Ugly-Kwame, M. Sierra, M. Munoz, Y. Mukadi, C. Nyarko, E. Vazquez de Parga, Y. Vega, R. Asare, R. Amenyah, R. Carmona, G. Casado, M. Thomson, R. Najera, High Prevalence of HIV-1 unique recombinant forms (URFs) in Ghana involving CRF02_AG, CRF06_cpx and CRF09_cpx, (Poster), 3rd IAS Conference on HIV Pathogenesis and Treatment, 24th-27th July 2005, Rio de Janeiro

 11. E. Delgado, W. Ampofo, K. Torpey, E. Ugly-Kwame, M. Sierra, M. Munoz, Y. Mukadi, C. Nyarko, E. Vazquez de Parga, Y. Vega, R. Asare, R. Amenyah, R. Carmona, G. Casado, M. Thomson, R. Najera. Characterization of near full-length genomes of subtype A3 and A3/CRF02_AG recombinant forms in Ghana (Poster), XVI International AIDS Conference, 13th-18th August 2006, Toronto Canada

12. Bonney  EY, Sackey ST and Brandful JAM., Genetic Analysis of HIV strains in Ghanaian HIV-1 and HIV-2 dually seroreactive specimens (Oral), Fourth Annual Research Meeting, Noguchi Memorial Institute for Medical Research, 2004, Accra

13. E Y Ugly-Kwame, W O Kumi, J A M Brandful, K Ishikawa, Prevalence of HIV-Related Opportunistic Diseases among Ghanaian HIV/AIDS Patients (Poster), XIV International AIDS Conference, 7th -12th July 2002, Barcelona


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