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    dorothyyeboah manu
                                           

Name:Prof. Dorothy Yeboah-Manu

Email:dyeboah-manu@noguchi.ug.edu.gh

Telephone:+233-302-501178/9

Department:Bacteriology

Administrative Role:Head of Department

 Research Interests

  • Bacteriology,
  • Host and Pathogen Interactions
  • Molecular Epidemiology of Bacterial Diseases of Public Health Importance

 

Projects

  1. Towards effective control of Buruli ulcer (STOP Buruli Project)
  2. Host-pathogen interactions in Buruli ulcer disease
  3. Causes of wound healing delay
  4. Transmission
  5. Diagnosis of Buruli ulcer
  6. Molecular Epidemiology of Tuberculosis in Ghana
  7. Understanding the genomic diversity between Mycobacterium africanum (MAF) and M. tuberculosis (MTB)
  8. Phenotypic and genotypic characterisation of M. africanum strains from Ghana

 

Recent Publications

  1. Koka, E., Yeboah-Manu, D., Okyere, D., Adongo, P. B., & Ahorlu, C. K. (2016). Cultural Understanding of Wounds, Buruli Ulcers and Their Management at the Obom Sub-district of the Ga South Municipality of the Greater Accra Region of Ghana. PLoS Neglected Tropical Diseases, 10(7), e0004825. doi:10.1371/journal.pntd.0004825.
  2. Lamelas A, Ampah KA, Aboagye S, Kerber S, Danso E, Asante-Poku A, …. Yeboah-Manu, D., Roltgen, K. (2016). Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana. PLoS Neglected Tropical Diseases, 10(7):e0004856. doi: 10.1371/journal.pntd.0004856.
  3. Kpeli G, Otchere ID, Lamelas A, Buultjens AL, Bulach D, Baines SL,…. Yeboah-Manu, D. (2016). Possible health-care associated transmission as a cause of secondary infection and population structure of Staphylococcus aureus isolates from two wound treatment centers in Ghana. New Microbes and New Infections. doi: 10.1016/j.nmni.2016.07.001
  4. Akorli, J., Gendrin, M., Pels, N. A., Yeboah-Manu, D., Christophides, G. K., & Wilson, M. D. (2016). Seasonality and Locality Affect the Diversity of Anopheles gambiae and Anopheles coluzzii Midgut Microbiota from Ghana. PloS One, 11(6), e0157529. doi:10.1371/journal.pone.0157529.
  5. Ampah, K. A., Pinho-Nascimento, C. A., Kerber, S., Asare, P., De-Graft D., Adu-Nti, F. . . . Yeboah-Manu, D., Pluschke, G.,Roltgen, K. (2016). Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana. PloS One, 11(6), e0156864. doi:10.1371/journal.pone.0156864.
  6. Otchere, I. D., Asante-Poku, A., Osei-Wusu, S., Baddoo, A., Sarpong, E., Ganiyu, A. H. . . . Yeboah-Manu, D. (2016). Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana. Tuberculosis. doi:http://dx.doi.org/10.1016/j.tube.2016.05.014.
  7. Ruf, M. T., Bolz, M., Vogel, M., Bayi, P. F., Bratschi, M. W., Sopho, G. E., Yeboah-Manu, D. . . . Pluschke, G. (2016). Spatial Distribution of Mycobacterium ulcerans in Buruli Ulcer Lesions: Implications for Laboratory Diagnosis. PLoS Neglected Tropical Diseases, 10(6), e0004767. doi:10.1371/journal.pntd.0004767.
  8. Aboagye, S. Y., Danso, E., Ampah, K. A., Nakobu, Z., Asare, P., Otchere, I. D. . . . Yeboah-Manu, D. (2016). Isolation of Nontuberculous Mycobacteria from the Environment of Buruli Ulcer Endemic Communities in Ghana. Applied and Environmental Microbiology. doi:10.1128/aem.01002-16.
  9. Sakyi, S. A., Aboagye, S. Y., Darko Otchere, I., & Yeboah-Manu, D. (2016). Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review. Canadian Journal of Infectious Diseases and Medical Microbiology, 2016, 10. doi:10.1155/2016/5310718.
  10. Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., Addo, P. G., Otchere, I. D., & Kissi-Twum, A. (2016b). In vitro antimycobacterial and cytotoxic data on medicinal plants used to treat tuberculosis. Data Brief, 7, 1124-1130. doi:10.1016/j.dib.2016.03.088.
  11. Tsouh Fokou, P. V., Kissi-Twum, A. A., Yeboah-Manu, D., Appiah-Opong, R., Addo, P., Tchokouaha Yamthe, L. R., . . . Nyarko, A. K. (2016). In Vitro Activity of Selected West African Medicinal Plants against Mycobacterium ulcerans Disease. Molecules, 21(4). doi: 10.3390/molecules21040445.
  12. Ampah, K. A., Asare, P., Binnah, D. D., Maccaulley, S., Opare, W., Roltgen, K. . . . Yeboah-Manu, D. (2016). Burden and Historical Trend of Buruli Ulcer Prevalence in Selected Communities along the Offin River of Ghana. PLoS Neglected Tropical Diseases, 10(4), e0004603. doi:10.1371/journal.pntd.0004603.
  13. Zumla, A., Rao, M., Wallis, R. S., Kaufmann, S. H., Rustomjee, R., Mwaba, P., Vilaplana, C., Yeboah-Manu, D., et al.. . . Host-Directed Therapies Network, C. (2016). Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. Lancet Infectious Diseases, 16(4), e47-63. doi:10.1016/S1473-3099(16)00078-5
  14. Ampah, K. A., Nickel, B., Asare, P., Ross, A., De-Graft, D., Kerber, S. . . Yeboah-Manu, D., Roltgen, K. (2016). A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans. PLoS Neglected Tropical Diseases, 10(1), e0004387. doi:10.1371/journal.pntd.0004387
  15. Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., Addo, P. G., Otchere, I., & Kissi-Twum, A. (2016a). Antimycobacterial and cytotoxic activity of selected medicinal plant extracts. Journal of Ethnopharmacology, 182, 10-15. doi:10.1016/j.jep.2016.02.010
  16. Ntoumi, F., Kaleebu, P., Macete, E., Mfinanga, S., Chakaya, J., Yeboah-Manu, D. . . . Zumla, A. (2016). Taking forward the World TB Day 2016 theme 'Unite to End Tuberculosis' for the WHO Africa Region. International Journal of Infectious Diseases, 46, 34-37. doi:10.1016/j.ijid.2016.03.003
  17. Zumla, A., Chakaya, J., Hoelscher, M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., et al. (2015). Towards host-directed therapies for tuberculosis. Nature Reviews Drug Discovery, 14(8):511–2.
  18. Asante-Poku, A., Otchere, I. D., Danso, E., Mensah, D. D., Bonsu, F., Gagneux, S., & Yeboah-Manu, D. (2015). Evaluation of GenoType® MTBDRplus for rapid detection of drug-resistant tuberculosis in Ghana. The International Journal of Tuberculosis and Lung Disease, 19(8), 954–9.
  19. Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., & Addo, P. G. A. (2015b). Current perspectives in drug discovery against tuberculosis from natural products. International Journal of Mycobacteriology, 4(3), 165-183.
  20. Zumla, A., Maeurer, M., & Host-Directed Therapies Network (HDT-NET) Consortium (2015). Host-Directed Therapies for tackling Multi-Drug Resistant TB – learning from the Pasteur-Bechamp debates. Clinical Infectious Diseases. doi: 10.1093/cid/civ631.

 

 

 

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