• Legon, Accra
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Clinical Pathology

Clinical Pathology Department

The Clinical Pathology Department conducts research that contributes to intervention strategies and safeguards of public health in Ghana. In view of this the Department carries out research into plant medicine development, drug interactions and regulation, bio-monitoring and prevention of poisoning from environmental toxicants (e.g. mycotoxins specifically aflatoxins and toxic heavy metals). The Department also provides specialized laboratory services in support of public health programmes.

Key Research Area of HOD

Drug development Drug-drug/ herb-drug/ food-drug interactions and drug metabolizing enzymes

  • Heavy metal studies

High Performance Liquid Chromatography (HPLC) instrument
Freeze dryer
Biosafety Cabinet
Lumex Mercury analyzer

Mycotoxin studies
i. Evaluation of palatability and acceptance of NovaSil- treated foods Investigators
ii. Modulation of rat liver microsomal protein-mediated aflatoxin biotransformation by Ghanaian vegetables
iii. Determination of fumonisins in weanimix

Drug Development
i. Chemicaland biological fingerprinting of Ghanaian medicinal plants
ii. Studies on Anti-viral and Anti-Parasitic Compounds from Selected Ghanaian Medicinal Plants: Toxicity of medicinal plants

Drug Interactions

  1. Survey on prevalence of co-use of plant and orthodox medicines in the Ga East District of Ghana.
  2. Cytochrome P450-mediated drug-drug and herb-drug interaction studies on drugs and herbal preparations used to treat malarial, tuberculosis and HIV


Laboratory tests conducted by the department include:


Total aflatoxin measurement (AFB1, AFB2, AG1 and AG2)

Aflatoxin M1 metabolite

Fumonisin (FB1) measurement


Lead, Cadmium, Zinc, Selenium, Arsenic, Mercury, Copper


Liver Function Test


Direct bilirubin

Total bilirubin

Total protein

Aspartate aminotransferase (AST)

Alanine aminotransferase (ALT)

Alkaline Phosphatase (ALP)

Gamma-glutamyl transpeptidase (GGT)

Kidney Function Test



Blood urea nitrogen

Electrolytes (Sodium, Potassium, chloride)

Lipid Profile

Total Cholesterol

High Density Lipoprotein (HDL)

Low Density Lipoprotein (LDL)


Glucose levels

Fasting blood glucose

Random blood glucose


Evaluation of Safety of herbal products – Acute, Subchronic and Chronic toxicity studies

Efficacy of herbal products – Anticancer and antimalarial activities


Prof. (Mrs.) Regina Appiah Opong

Senior Research Fellow (Head of Dept.)

Dr. Mark Ofosuhene

Research Fellow

Ms. Abigail Aning Senior Research Assistant
Mr. Isaac Tuffour Senior Research Assistant

Mr. Kojo Agyeman

Research Assistant

Ms. Eunice Dotse

Research Assistant

Mr. Justice Kumi Principal Research Assistant

Mrs. Eunice E. Ampem Danso

Laboratory Technologist

Mr. Ebenezer Ofori-Attah

Laboratory Technician

Mr. Francis Attigah

Assistant technician

Ms. Gloria Aku Darko

Senior Administrative Assistant

The Noguchi Memorial Institute for Medical Research (NMIMR), set up in 1979 as a semi autonomous institute of the University, is the leading biomedical research facility in Ghana.

© 2017 NMIMR

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